Rabbit
The improvement in rabbits’ health due to better sanitation and nutrition has made the breeding and maintaining rabbit populations more manageable and more effective as research tools. These changes to the method we care for rabbits is mostly the result of the knowledge of the rabbit’s physiology acquired from medical study.
The general nature of the rabbit’s
physiology is similar to human physiology as well as mice. Like rodents, rabbits are affected by various diseases that have human counterparts. Young rabbits are often afflicted with mucoid Enteritis, a condition that is similar to cystic fibrosis and the cholera. Rabbits can be utilized as models that can aid in understanding these conditions.
In the past, Louis Pasteur used rabbits in the development of his vaccine against rabies and rabbits have been crucial in the research of cardiovascular diseases, specifically atherosclerosis and hypertension.The studies conducted on rabbits are crucial to many areas of medical research. These include cancer and glaucoma, ear infections eye infections, skin disorders as well as diabetes and emphysema.
Production of antibodies
One of the most frequent uses for rabbits in the lab is the production of antibodies, which are used to identify whether or not a disease is present as well as for studies into immune diseases and infections. Antibodies are an essential element in the adaptive immune system, the component that is part of our immune system that specifically recognizes foreign invaders. They are complex proteins that can only be made through the immune system in a living animal. They recognise and bind to specific proteins.
To create antibodies,
the rabbit is injected an amino acid sequence from the pathogen to be examined. New Zealand white rabbits are commonly used as their size guarantees that there is plenty of antiserum created. Antibody is generated from the body’s immuno system and the progression of production of antibodies is tracked by taking small blood samples regularly. Blue Birds in Michigan When a sufficient amount of antibody is produced it is then extracted of the animal under anaesthetic. The antiserum produced by a single rabbit lasts for a considerable period of time and generates an enormous amount of antibodies which is typically utilized for a number of years. There is currently no alternative to the use of animals to produce antibodies however it is a subject of ongoing study in the best method for producing antibodies.
Laser surgery
The rabbit provides an excellent model system that can show the human tissues to the radiation generated from surgical lasers. The advancements in laser technology that have been that are possible due to research conducted on rabbits are eye surgery as well as the removal of plaque within the walls blood vessels.
High cholesterol
The genetic disorder known as familial hypercholesterolemia can cause blood cholesterol levels to be up to seven times more than what is normal for human beings. Do Birds Pee Atherosclerosis is caused by high cholesterol – the accumulation of fat deposits within the arteries, which severely limit blood flow. Those who suffer from this condition typically suffer heart attacks in the early years of their life.
The Watanabe rabbit is plagued by extremely high levels of blood cholesterol due to a genetic flaw which is similar to the fatal human condition . they are prone to heart attacks before the age of 2. The rabbits are used as models for more effective treatments for children suffering from this condition, as well as to conduct general research on high cholesterol levels. Research using these rabbits has included the development of an artificial liver to remove excess cholesterol from the blood of children suffering from hypercholesterolemia.
Animal(s): Rabbit
Researchers field(s): Anatomy and development, Biochemistry muscles and bones, brain as well as the nervous system. cancer research, cell biology, disease features, Drugs and Toxins and Endocrinology (hormones) Genetics and evolution Heart, lung and circulation Infection and Immunity and Medical technology Psychology and behaviourmedical application(s): Basic research Medical Surgery, Vaccine
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